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Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design.

机译：通过片段筛选和基于结构的设计鉴定人免疫缺陷病毒整合酶的LEDGF位点的小分子抑制剂。

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Thomas S Peat; David I Rhodes; Nick Vandegraaff; Giang Le; Jessica A Smith; Lisa J Clark; Eric D Jones; Jonathan A V Coates; Neeranat Thienthong; Janet Newman; Olan Dolezal; Roger Mulder; John H Ryan; G Paul Savage; Craig L Francis; John J Deadman;
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1. Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design. [J] . Rhodes DI, Peat TS, Vandegraaff N, Antiviral chemistry & chemotherapy . 2011,第4期

机译：通过片段筛选和基于结构的设计确定了抑制HIV-1整合酶的新机制的结构基础。
2. Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design. [J] . Rhodes DI, Peat TS, Vandegraaff N, Antiviral chemistry & chemotherapy . 2011,第4期

机译：基于碎片筛选和基于结构的设计鉴定的HIV-1整合酶的新机制的结构基础。
3. Structure-based virtual screening toward the discovery of novel inhibitors for impeding the protein-protein interaction between HIV-1 integrase and human lens epithelium-derived growth factor (LEDGF/p75) [J] . Panwar Umesh, Singh Sanjeev Kumar Journal of Biomolecular Structure and Dynamics . 2018,第11a12期

机译：基于结构的虚拟筛选，用于发现新型抑制剂，用于阻碍HIV-1整合酶与人晶状体上皮衍生的生长因子（LEDGF / P75）之间的蛋白质 - 蛋白质相互作用
4. G-Quadruplexes in the Human Immunodeficiency Virus-1 and Herpes Simplex Virus-1: New Targets for Antiviral Activity by Small Molecules [C] . Rosalba Perrone, Sara Artusi, Elena Butovskaya International Conference on Biomedical Engineering in Vietnam . 2015

机译：人类免疫缺陷病毒-1中的G-Quadruplees和单纯疱疹病毒-1：小分子的抗病毒活动的新靶标
5. Characterization of a Human Immunodeficiency Virus (HIV) Type I Integrase Inhibitor-Binding Pocket and Discovery of Novel Inhibitors Potent against Drug-Resistant Variants of HIV [D] . Crosby, David Charles 2010

机译：人类免疫缺陷病毒（HIV）I型整合酶抑制剂结合口袋的表征和新型抗HIV药物耐药变体的抑制剂的发现
6. Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design [O] . Thomas S. Peat, David I. Rhodes, Nick Vandegraaff, 2009

机译：通过片段筛选和基于结构的设计鉴定人免疫缺陷病毒整合酶LEDGF位点的小分子抑制剂
7. Corrigendum: Fragment-Based Design of Ligands Targeting a Novel Site on the Integrase Enzyme of Human Immunodeficiency Virus 1 [O] . Jerome Wielens, Stephen J. Headey, John J. Deadman, 2011

机译：勘误：基于片段的配体设计，靶向人类免疫缺陷病毒的整体酶1的新立场1

Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design.

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